COQ3 Antibody

Product: Benzethonium chloride

COQ3 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids:KWWDEQGVYAPLHSMNDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPV
Specificity
Specificity of antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
COQ3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:500
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
For IHC-Paraffin HIER pH6 retrieval is recommended.
Control Peptide
COQ3 Protein (NBP1-88725PEP)

Reactivity Notes

Expected species cross reactivity based on sequence homology: Mouse (86%), Rat (89%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for COQ3 Antibody

  • 3-demethylubiquinone-10 3-methyltransferase
  • bA9819.1
  • coenzyme Q3 homolog, methyltransferase (S. cerevisiae)
  • coenzyme Q3 homolog, methyltransferase (yeast)
  • DHHB methyltransferase
  • DHHBMT
  • DHHB-MT
  • DHHBMTASE
  • DHHB-MTase
  • Dihydroxyhexaprenylbenzoate methyltransferase
  • EC 2.1.1
  • EC 2.1.1.114
  • EC 2.1.1.64
  • hexaprenyldihydroxybenzoate methyltransferase, mitochondrial3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
  • methyltransferase COQ3
  • UG0215E05

PMID: 2571177

COQ3 Antibody

Product: PIM449

COQ3 Antibody Summary

Immunogen
COQ3 (AAH63463.1, 1 a.a. ~ 369 a.a) full-length human protein.MWSGRKLGSSGGWFLRVLGPGGCNTKAARPLISSAVYVKNQLSGTLQIKPGVFNEYRTIWFKSYRTIFSCLNRIKSFRYPWARLYSTSQTTVDSGEVKTFLALAHKWWDEQGVYAPLHSMNDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLGASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINK
Specificity
COQ3 – coenzyme Q3 homolog, methyltransferase (yeast),
Clonality
Polyclonal
Host
Mouse
Gene
COQ3
Purity
Protein A purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

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Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control. Has also been used for immunohistochemistry (paraffin).

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for COQ3 Antibody

  • 3-demethylubiquinone-10 3-methyltransferase
  • bA9819.1
  • coenzyme Q3 homolog, methyltransferase (S. cerevisiae)
  • coenzyme Q3 homolog, methyltransferase (yeast)
  • DHHB methyltransferase
  • DHHBMT
  • DHHB-MT
  • DHHBMTASE
  • DHHB-MTase
  • Dihydroxyhexaprenylbenzoate methyltransferase
  • EC 2.1.1
  • EC 2.1.1.114
  • EC 2.1.1.64
  • hexaprenyldihydroxybenzoate methyltransferase, mitochondrial3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase
  • methyltransferase COQ3
  • UG0215E05

Background

Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM]

PMID: 1335533