Product Name :
Rabbit anti-IL17A Polyclonal Antibody
Synonym :
CTLA-8; CTLA8; IL-17; IL-17A; IL17
Host :
Rabbit
Species Reactivity:
Human
Specificity :
Predicted Reactivity:
Applications :
WB 1:200 – 1:500
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1).
Concentration :
Purification :
Affinity purification
Clonality:
Storage Temp.:
Store at -20 ℃Avoid freeze / that cycles
Research areas :
Background :
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
UniProt :
Q16552
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym CTLA-8; CTLA8; IL-17; IL-17A; IL17 |Host Rabbit |Species Reactivity Human |Applications WB 1:200 – 1:500 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 24-155 of human IL17A (NP_002181.1). |Properties |Purification Affinity purification |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Store at -20 °C.Stable for 12 months from date of receipt. |Target |Background The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |Cellular localization Secreted |UniProt Q16552 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-IL17A Polyclonal Antibody
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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