Product Name :
MMV390048
Description:
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.
CAS:
1314883-11-8
Molecular Weight:
393.38
Formula:
C18H14F3N3O2S
Chemical Name:
5-(4-methanesulfonylphenyl)-6′-(trifluoromethyl)-[3,3′-bipyridin]-2-amine
Smiles :
CS(=O)(=O)C1C=CC(=CC=1)C1=CC(=C(N)N=C1)C1=CN=C(C=C1)C(F)(F)F
InChiKey:
RTJQABCNNLMCJF-UHFFFAOYSA-N
InChi :
InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.|Product information|CAS Number: 1314883-11-8|Molecular Weight: 393.38|Formula: C18H14F3N3O2S|Chemical Name: 5-(4-methanesulfonylphenyl)-6′-(trifluoromethyl)-[3,3′-bipyridin]-2-amine|Smiles: CS(=O)(=O)C1C=CC(=CC=1)C1=CC(=C(N)N=C1)C1=CN=C(C=C1)C(F)(F)F|InChiKey: RTJQABCNNLMCJF-UHFFFAOYSA-N|InChi: InChI=1S/C18H14F3N3O2S/c1-27(25,26)14-5-2-11(3-6-14)13-8-15(17(22)24-10-13)12-4-7-16(23-9-12)18(19,20)21/h2-10H,1H3,(H2,22,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sofosbuvir} web|{Sofosbuvir} Anti-infection|{Sofosbuvir} Protocol|{Sofosbuvir} References|{Sofosbuvir} custom synthesis|{Sofosbuvir} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Guselkumab} site|{Guselkumab} Immunology/Inflammation|{Guselkumab} Biological Activity|{Guselkumab} Formula|{Guselkumab} manufacturer|{Guselkumab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33090317 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MMV390048 against intraerythrocytic life cycle stages of P. falciparum (NF54 drug-sensitive strain) showed a steep inhibition curve with IC50 and IC90 values of 28 and 40 nM, respectively.|Products are for research use only. Not for human use.|