Product Name :
Chlorothricin
Description:
IC50: 173, 500, 260, and 120 μM for pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken, respectively. Chlorothricin is a macrolide-type antibiotic. Macrolides, a class of natural products belonging to the polyketide class of natural products, consist of a large macrocyclic lactone ring. The lactone rings are oftem 14-, 15-, or 16-membered. Some macrolides have been reported to have antibiotic or antifungal activity and are widely used as pharmaceutical drugs. In vitro: In a previous study, chlorothricin was found to inhibit the reaction catalyzed by pyruvate carboxylase from Bacillus stearothermophilus. Moreover, with steady-state kinetic measurements, inhibition of the overall reaction was found to be competitive with the allosteric activator of this enzyme, CoASAc, and non-competitive with respect to both substrates of MgATP and pyruvate. These findings strongly indicated that the site 1conformation of pyruvate carboxylase responsible for the regulation of the overall enzyme activity could be influenced by chlorothricin and CoASAc in an antagonistic manner . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.
CAS:
34707-92-1
Molecular Weight:
955.48
Formula:
C50H63ClO16
Chemical Name:
(1S,3R,6R,13R,16S,17S,21R,22R)-17-{[(2R,4R,5S,6R)-5-{[(2S,4R,5R,6R)-4-(3-chloro-6-methoxy-2-methylbenzoyloxy)-5-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-28-hydroxy-3,22-dimethyl-23,26-dioxo-24,27-dioxapentacyclo[23.2.1.0¹,⁶.0¹³,²².0¹⁶,²¹]octacosa-4,7,14,25(28)-tetraene-4-carboxylic acid
Smiles :
C[C@]12[C@@H]3CCC[C@H](O[C@H]4C[C@@H](O)[C@H](O[C@H]5C[C@@H](OC(=O)C6=C(C=CC(Cl)=C6C)OC)[C@H](O)[C@@H](C)O5)[C@@H](C)O4)[C@H]3C=C[C@H]1CCCCC=C[C@@H]1C=C([C@H](C)C[C@@]31OC(=O)C(OC2=O)=C3O)C(O)=O |c:51|
InChiKey:
WUXHQHDSSKBJFH-LTBGADRXSA-N
InChi :
InChI=1S/C50H63ClO16/c1-24-23-50-29(20-31(24)45(55)56)13-10-8-7-9-12-28-16-17-30-32(49(28,5)48(59)66-43(44(50)54)47(58)67-50)14-11-15-35(30)63-38-21-34(52)42(27(4)62-38)65-39-22-37(41(53)26(3)61-39)64-46(57)40-25(2)33(51)18-19-36(40)60-6/h10,13,16-20,24,26-30,32,34-35,37-39,41-42,52-54H,7-9,11-12,14-15,21-23H2,1-6H3,(H,55,56)/b13-10-/t24-,26-,27-,28-,29-,30+,32-,34-,35+,37-,38+,39+,41-,42-,49-,50+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IC50: 173, 500, 260, and 120 μM for pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken, respectively. Chlorothricin is a macrolide-type antibiotic. Macrolides, a class of natural products belonging to the polyketide class of natural products, consist of a large macrocyclic lactone ring.{{Cediranib} medchemexpress|{Cediranib} Protein Tyrosine Kinase/RTK|{Cediranib} TGF-beta/Smad|{Cediranib} Biological Activity|{Cediranib} Formula|{Cediranib} supplier} The lactone rings are oftem 14-, 15-, or 16-membered.{{Isorhamnetin} site|{Isorhamnetin} MAPK/ERK Pathway|{Isorhamnetin} Technical Information|{Isorhamnetin} Formula|{Isorhamnetin} custom synthesis|{Isorhamnetin} Autophagy} Some macrolides have been reported to have antibiotic or antifungal activity and are widely used as pharmaceutical drugs. In vitro: In a previous study, chlorothricin was found to inhibit the reaction catalyzed by pyruvate carboxylase from Bacillus stearothermophilus. Moreover, with steady-state kinetic measurements, inhibition of the overall reaction was found to be competitive with the allosteric activator of this enzyme, CoASAc, and non-competitive with respect to both substrates of MgATP and pyruvate.PMID:35954127 These findings strongly indicated that the site 1conformation of pyruvate carboxylase responsible for the regulation of the overall enzyme activity could be influenced by chlorothricin and CoASAc in an antagonistic manner . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 34707-92-1|Molecular Weight: 955.48|Formula: C50H63ClO16|Chemical Name: (1S,3R,6R,13R,16S,17S,21R,22R)-17-{[(2R,4R,5S,6R)-5-{[(2S,4R,5R,6R)-4-(3-chloro-6-methoxy-2-methylbenzoyloxy)-5-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-28-hydroxy-3,22-dimethyl-23,26-dioxo-24,27-dioxapentacyclo[23.2.1.0¹,⁶.0¹³,²².0¹⁶,²¹]octacosa-4,7,14,25(28)-tetraene-4-carboxylic acid|Smiles: C[C@]12[C@@H]3CCC[C@H](O[C@H]4C[C@@H](O)[C@H](O[C@H]5C[C@@H](OC(=O)C6=C(C=CC(Cl)=C6C)OC)[C@H](O)[C@@H](C)O5)[C@@H](C)O4)[C@H]3C=C[C@H]1CCCCC=C[C@@H]1C=C([C@H](C)C[C@@]31OC(=O)C(OC2=O)=C3O)C(O)=O |c:51||InChiKey: WUXHQHDSSKBJFH-LTBGADRXSA-N|InChi: InChI=1S/C50H63ClO16/c1-24-23-50-29(20-31(24)45(55)56)13-10-8-7-9-12-28-16-17-30-32(49(28,5)48(59)66-43(44(50)54)47(58)67-50)14-11-15-35(30)63-38-21-34(52)42(27(4)62-38)65-39-22-37(41(53)26(3)61-39)64-46(57)40-25(2)33(51)18-19-36(40)60-6/h10,13,16-20,24,26-30,32,34-35,37-39,41-42,52-54H,7-9,11-12,14-15,21-23H2,1-6H3,(H,55,56)/b13-10-/t24-,26-,27-,28-,29-,30+,32-,34-,35+,37-,38+,39+,41-,42-,49-,50+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|