Product Name :
DUN09716
Description:
DUN09716 is KRAS inhibitor with potential antitumor activity. DUN09716 was reported inn patent US 9884046.
CAS:
300809-71-6
Molecular Weight:
292.81
Formula:
C13H9ClN2S2
Chemical Name:
4-[(Benzo[d]thiazol-2-yl)thio]-3-chloroaniline
Smiles :
NC1=CC(Cl)=C(C=C1)SC1=NC2=CC=CC=C2S1
InChiKey:
DTSNLMOLTVGCGZ-UHFFFAOYSA-N
InChi :
InChI=1S/C13H9ClN2S2/c14-9-7-8(15)5-6-11(9)17-13-16-10-3-1-2-4-12(10)18-13/h1-7H,15H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DUN09716 is KRAS inhibitor with potential antitumor activity. DUN09716 was reported inn patent US 9884046.|Product information|CAS Number: 300809-71-6|Molecular Weight: 292.81|Formula: C13H9ClN2S2|Synonym:|DUN-09716|DUN 09716|Chemical Name: 4-[(Benzo[d]thiazol-2-yl)thio]-3-chloroaniline|Smiles: NC1=CC(Cl)=C(C=C1)SC1=NC2=CC=CC=C2S1|InChiKey: DTSNLMOLTVGCGZ-UHFFFAOYSA-N|InChi: InChI=1S/C13H9ClN2S2/c14-9-7-8(15)5-6-11(9)17-13-16-10-3-1-2-4-12(10)18-13/h1-7H,15H2|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (853.80 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{R-Phycoerythrin} MedChemExpress|{R-Phycoerythrin} {Fluorescent Dye}|{R-Phycoerythrin} Protocol|{R-Phycoerythrin} Data Sheet|{R-Phycoerythrin} custom synthesis|{R-Phycoerythrin} Autophagy} |Shelf Life: ≥360 days if stored properly.{{Anamorelin} site|{Anamorelin} GPCR/G Protein|{Anamorelin} Purity & Documentation|{Anamorelin} Purity|{Anamorelin} supplier|{Anamorelin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35954127 |Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|DUN09716 bound to KRASG12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity of -5.38, -5.41, and -3.97 kcal/mol, respectively. DUN09716 (0-100 μM) shows strong inhibition selectivity in NSCLC cells with IC50s ranging from 39.56 to 66.02 μM for H2122, H358 and H460 cells (at 72 hours). DUN09716 (0-100 μM; 24 hours) blocks GTP-KRAS formation in H2122, H358 and H460 cells. DUN09716 (25-100 μM; 48 hours) inhibits the activation of KRAS downstream signaling pathway. DUN09716 (0-100 μM; 24-72 hours) induces cell cycle arrest and apoptosis in NSCLC.|References:|Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.Products are for research use only. Not for human use.|