Product Name :
OG-L002 — LSD1 Inhibitor
Description:
OG-L002 is a highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1.38 µM and 0.72µM respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG-L002 suppressed primary lytic infection of HSV in vivo in a mouse model.
CAS:
1357302-64-7
Molecular Weight:
225.29
Formula:
C15H15NO
Chemical Name:
4′-((1S,2R)-2-aminocyclopropyl)-[1,1′-biphenyl]-3-ol
Smiles :
N[C@@H]1C[C@H]1C1C=CC(=CC=1)C1=CC(O)=CC=C1
InChiKey:
DSOJSZXQRJGBCW-LSDHHAIUSA-N
InChi :
InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Biotin-PEG4-NHS ester} MedChemExpress|{Biotin-PEG4-NHS ester} PROTAC Linkers|{Biotin-PEG4-NHS ester} Epigenetics|{Biotin-PEG4-NHS ester} Biological Activity|{Biotin-PEG4-NHS ester} Description|{Biotin-PEG4-NHS ester} supplier}
Additional information:
OG-L002 is a highly potent and specific inhibitor of Lysine Specific Demethylase-1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~20 nM, and has moderate inhibitory activity against monoamine oxidases MAO-A and MAO-B with IC50 ~1.{{Capreomycin} site|{Capreomycin} Antibiotic|{Capreomycin} Technical Information|{Capreomycin} Purity|{Capreomycin} supplier|{Capreomycin} Cancer} 38 µM and 0.PMID:23916866 72µM respectively. It potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. OG-L002 suppressed primary lytic infection of HSV in vivo in a mouse model.|Product information|CAS Number: 1357302-64-7|Molecular Weight: 225.29|Formula: C15H15NO|Chemical Name: 4′-((1S,2R)-2-aminocyclopropyl)-[1,1′-biphenyl]-3-ol|Smiles: N[C@@H]1C[C@H]1C1C=CC(=CC=1)C1=CC(O)=CC=C1|InChiKey: DSOJSZXQRJGBCW-LSDHHAIUSA-N|InChi: InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m0/s1|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|OG-L002 was used at 1 µM in vitro.|In Vivo:|OG-L002 was administered by intraperitoneal injection once a day at a dose of 20-40 mg/kg to the primary infection mouse model.|References:|Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. (2013) MBio. 4(1):e00558-12.Products are for research use only. Not for human use.|Documents||