Product Name :
bis(7)-Tacrine
Description:
IC50: 0.40 nM bis(7)-Tacrine is an AChE inhibitor. Acetylcholinesterase ( AChE), the primary cholinesterase in the body, is an enzyme catalyzing the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters. In vitro: bis(7)-Tacrine, the 9-amino-1,2,3,4-tetrahydroacridine (THA) dimer, was identified as a promising drug candidate for the palliative treatment of Alzheimer’s disease, due to its significant enhancement in acetylcholinesterase (AChE) inhibition potency and AChE/butyrylcholinesterase (BChE) selectivity relative to THA itself. Enzyme kinetic studies performed in rat cortex found that both bis(7)-tacrine and THA exhibited mixed inhibition, and the rat cortex KI values were consistent with the previously determined human cerebellum Ki values . Clinical trial: So far, no clinical study has been conducted.
CAS:
224445-12-9
Molecular Weight:
565.62
Formula:
C33H42Cl2N4
Chemical Name:
N1,N7-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine dihydrochloride
Smiles :
Cl.Cl.C1CCCC2C(NCCCCCCCNC3C4=CC=CC=C4N=C4CCCCC4=3)=C3C=CC=CC3=NC=21
InChiKey:
RHKXINFBJWDTSK-UHFFFAOYSA-N
InChi :
InChI=1S/C33H40N4.2ClH/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33;;/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37);2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IC50: 0.40 nM bis(7)-Tacrine is an AChE inhibitor.{{Sumatriptan} medchemexpress|{Sumatriptan} GPCR/G Protein|{Sumatriptan} Purity & Documentation|{Sumatriptan} Description|{Sumatriptan} custom synthesis|{Sumatriptan} Epigenetic Reader Domain} Acetylcholinesterase ( AChE), the primary cholinesterase in the body, is an enzyme catalyzing the breakdown of acetylcholine and of some other choline esters that function as neurotransmitters.{{Naxitamab} site|{Naxitamab} Purity & Documentation|{Naxitamab} References|{Naxitamab} supplier|{Naxitamab} Cancer} In vitro: bis(7)-Tacrine, the 9-amino-1,2,3,4-tetrahydroacridine (THA) dimer, was identified as a promising drug candidate for the palliative treatment of Alzheimer’s disease, due to its significant enhancement in acetylcholinesterase (AChE) inhibition potency and AChE/butyrylcholinesterase (BChE) selectivity relative to THA itself.PMID:24563649 Enzyme kinetic studies performed in rat cortex found that both bis(7)-tacrine and THA exhibited mixed inhibition, and the rat cortex KI values were consistent with the previously determined human cerebellum Ki values . Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 224445-12-9|Molecular Weight: 565.62|Formula: C33H42Cl2N4|Chemical Name: N1,N7-bis(1,2,3,4-tetrahydroacridin-9-yl)heptane-1,7-diamine dihydrochloride|Smiles: Cl.Cl.C1CCCC2C(NCCCCCCCNC3C4=CC=CC=C4N=C4CCCCC4=3)=C3C=CC=CC3=NC=21|InChiKey: RHKXINFBJWDTSK-UHFFFAOYSA-N|InChi: InChI=1S/C33H40N4.2ClH/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33;;/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|