Melanocortin-1 R/MC1R Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC1 Receptor.
|
| Epitope |
3rd cytoplasmic domain of human
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| Specificity |
Human MC1 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
MC1R
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey (100%); Baboon, Cat, Panda (94%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Melanocortin-1 R/MC1R Antibody
- CMM5
- MC1R
- MC1-R
- melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
- Melanocortin receptor 1
- Melanocortin-1 R
- Melanocortin1R
- Melanocortin-1R
- melanocyte-stimulating hormone receptor
- melanotropin receptor
- MSHR
- MSH-R
- Mshra
- MSH-RMGC14337
- SHEP2
- Tob
Background
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.