DAD1 Antibody Summary
| Immunogen |
Synthetic peptide from human DAD1.
|
| Specificity |
peptide corresponding to 14 amino acids near the C-terminus of human DAD1
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
DAD1
|
| Purity |
Ion exchange chromatography
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Ion exchange chromatography
|
Alternate Names for DAD1 Antibody
- DAD-1
- defender against cell death 1EC 2.4.1.119
- dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit DAD1
- Oligosaccharyl transferase subunit DAD1
- oligosaccharyltransferase 2 homolog
- OST2
Background
Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death, a process important for normal organism development and tissue homeostasis. DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity. Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death. Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.