HSPA8/HSC71/Hsc70 Antibody (plant) Summary
| Immunogen |
Recombinant spinach Hsc70 (Hsp73).
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| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
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| Gene |
HSPA8
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
|
| Application Notes |
This antibody is useful in Immunoprecipitation and Western Blot. Detects a band of ~78kDa by Western blot.
|
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| Publications |
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Reactivity Notes
Pig and Plant
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS and 50% Glycerol
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for HSPA8/HSC71/Hsc70 Antibody (plant)
- Heat shock 70 kDa protein 8
- heat shock 70kD protein 8
- heat shock 70kDa protein 8
- heat shock cognate 71 kDa protein
- heat shock cognate protein 54
- heat shock cognate protein, 71-kDa
- HSC54
- HSC70
- HSC70heat shock 70kd protein 10
- HSC71
- HSP71
- HSP73
- HSP73constitutive heat shock protein 70
- HSPA10
- HSPA8
- LAP1
- lipopolysaccharide-associated protein 1
- LPS-associated protein 1
- MGC131511
- MGC29929
- NIP71
- N-myristoyltransferase inhibitor protein 71
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.