Product: Bax inhibitor peptide V5
MCAM/CD146 Antibody (c264) Summary
| Immunogen |
Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos
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| Specificity |
Chicken MCAM, Mr 98 kDa (protein core approx. 84 kDa)
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MCAM
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Chicken
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
0.1M BBS (pH 8.2)
|
| Preservative |
No Preservative
|
| Purity |
Protein A or G purified
|
Alternate Names for MCAM/CD146 Antibody (c264)
- CD146 antigen
- CD146
- cell surface glycoprotein MUC18
- Cell surface glycoprotein P1H12
- L-Gicerin
- MCAM
- melanoma adhesion molecule
- melanoma cell adhesion moleculeS-endo 1 endothelial-associated antigen
- Melanoma-associated antigen A32
- Melanoma-associated antigen MUC18
- MUC18
- MUC18Gicerin
Background
Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilms kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit+ hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes. (1)