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Lung cancerERK and AKT phosphorylation status in lung cancer and emphysema employing nanocapillary isoelectric focusingPhilip A J Crosbie,1,2 Emma J Crosbie,three Mark AspinallO’Dea,two Michael Walker,two Rebecca Harrison,four Maria Pernemalm,5 Rajesh Shah,six Leena Joseph,7 Richard Booton,1 Andrew Pierce,2 Anthony D WhettonTo cite: Crosbie PAJ, Crosbie EJ, AspinallO’Dea M, et al. ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing. BMJ Open Resp Res 2016;three: e000114. doi:ten.1136 bmjresp2015ABSTRACT Background: Emphysema is an independent riskfactor for the improvement of lung cancer in smokers. Activation of oncogenic signalling proteins AKT and ERK by phosphorylation has an established part in the development of lung cancer and has also been implicated inside the pathogenesis of emphysema. The aim of this study was to examine the protein level and phosphorylation status of AKT and ERK in paired lung cancer and emphysema tissue making use of a extremely sensitive phosphoprotein evaluation approach. Strategies: An antibodybased, nanocapillary isoelectric focusing (cIEF) assay was made use of to figure out the relative quantities and phosphorylation status of AKT and ERK in tumour and matched lung tissue from sufferers, with or without having proof of emphysema, undergoing curative resection for nonsmall cell lung cancer. Results: 20 sufferers with adenocarcinoma (n=9) or squamous cell carcinoma (n=11) of your lung wer.