Orai1 Antibody Summary
| Immunogen |
Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1. The immunogen is located within the last 50 amino acids of ORAI1.
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| Specificity |
This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ORAI1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Orai1 Antibody
- CRACM1
- CRACM1ORAT1
- FLJ14466
- ORAI calcium release-activated calcium modulator 1
- Orai1
- ORAT1
- Protein orai-1
- TMEM142A
- TMEM142Acalcium release-activated calcium modulator 1
- Transmembrane protein 142Acalcium release-activated calcium channel protein 1
Background
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.