Daxx Antibody Summary
| Immunogen |
Antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human Daxx. The immunogen is located within the last 50 amino acids of Daxx.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
DAXX
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| Purity |
Ion exchange chromatography
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Daxx antibody can be used for detection of Daxx by Western blot at 1 – 2 mg/ml. A 120 kDa major band can be detected.
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| Theoretical MW |
120 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Ion exchange chromatography
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Alternate Names for Daxx Antibody
- BING2
- CENP-C binding protein
- DAP6
- DAP6MGC126245
- Daxx
- death domain-associated protein 6
- death-associated protein 6
- death-domain associated protein
- EAP1
- ETS1-associated protein 1
- Fas death domain-associated protein
- Fas-binding protein
- hDaxx
- MGC126246
Background
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.