Nudel Antibody Summary
| Immunogen |
Antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Nudel. The immunogen is located within the first 50 amino acids of Nudel.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NDEL1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Nudel antibody can be used for detection of Nudel by Western blot at 0.5 – 1 mg/ml.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Nudel Antibody
- DKFZp451M0318
- EOPA
- MITAP1mitosin-associated protein MITAP1
- Mitosin-associated protein 1
- nuclear distribution protein nudE-like 1
- nudE nuclear distribution gene E homolog (A. nidulans)-like 1
- nudE nuclear distribution gene E homolog like 1 (A. nidulans)
- nudE nuclear distribution gene E homolog like 1
- NUDELendooligopeptidase A
- NUDE-like protein
- Protein Nudel
Background
Nudel was initially discovered as a protein homologous to Aspergillus NUDE and that associated with Lis1 and polyprotein complex cytoplasmic dynein, both of which have been linked to neuronal development and migration. It was later shown to be a substrate of cdk5, a kinase known to be critical during neuronal migration; phosphorylation of Nudel by cdk5 affects its localization in neurons and affects neuritic morphology. It is thought that together with Lis1, Nudel regulates cytoplasmic dynein, a large polyprotein complex, in neuronal migration and mitosis through direct interactions. Similar interactions are thought to also play a role in membrane traffic in other cells as disruption of Nudel expression through RNA interference perturbed normal endomembrane flux and resulted in the fragmentation of the Golgi apparatus.