HGF R/c-MET Antibody (4AT259) Summary
| Immunogen |
This monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
MET
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| Purity |
Protein G purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.09% Sodium Azide
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| Purity |
Protein G purified
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Alternate Names for HGF R/c-MET Antibody (4AT259)
- AUTS9
- cMET
- c-MET
- EC 2.7.10
- EC 2.7.10.1
- hepatocyte growth factor receptor
- HGF R
- HGF receptor
- HGF/SF receptor
- HGFR
- Met (c-Met)
- met proto-oncogene (hepatocyte growth factor receptor)
- met proto-oncogene tyrosine kinase
- MET
- oncogene MET
- Proto-oncogene c-Met
- RCCP2
- Scatter factor receptor
- SF receptor
- Tyrosine-protein kinase Met
Background
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.