PAC1R Antibody Summary
| Immunogen |
Synthetic 17 amino acid peptide from C-terminus of human ADCYAP1R1.
|
| Localization |
Cell Membrane
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| Specificity |
Human ADCYAP1R1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Fish (94%), Zebrafish (94%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ADCYAP1R1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (100%), Lizard (100%), Stickleback (94%), Pufferfish (94%0, Mouse (88%), Rat (88%), Hamster (88%), Elephant (88%), Bovine (88%), Equine (88%), Porcine (88%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
|
Alternate Names for PAC1R Antibody
- ADCYAP1R1
- adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1
- adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
- PAC1R
- PACAP type I receptor
- PACAPR
- PACAP-R1
- PACAP-R-1
- PACAPRI
- PACAPRPAC1
- pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
- pituitary adenylate cyclase-activating polypeptide type I receptor
Background
The PACAP receptor type 1, a member of the vasoactive intestinal polypeptide subfamily, binds the hormone pituitary adenylate cyclase activating polypeptide (PACAP) with high affinity. PACAP is involved in stimulating the secretion of insulin, catecholamines, ACTH, and growth hormone. Additionally, PACAP appears to function as a neuromodulator/neurotransmitter in the central and peripheral nervous systems. Two start codons are reported in literature, one (nt 74-76) results in a 525-amino acid protein with a signal peptide of 77 amino acids encoded by nt 74-304 and the second (nt 245-247) initiates a 468-amino acid protein with a signal peptide of 20-amino acids encoded by nt 245-304. The efficiency of these two start codons is not known. PACAP receptor type 1 expression has been documented in adipose, adrenal, bone, brain, colon, ganglion, heart, lung, ovary, pancreas, placenta, spleen, and uterus. ESTs have been isolated from brain and nerve libraries.