Product: Angiotensin II 5-valine
PUMA Antibody Summary
| Immunogen |
Reacts with a 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-alpha and PUMA-beta forms of the protein. Recognizes both forms of the protein.
|
| Localization |
Mitochondrial
|
| Specificity |
Human PUMA protein
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
BBC3
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
|
| Application Notes |
This antibody can be used in western blot, where the predicted molecular weight is 20 kDa.
|
|
| Publications |
|
Reactivity Notes
Reacts with human. 88% sequence identity with rat and mouse proteins.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PUMA Antibody
- BCL2 binding component 3
- bcl-2-binding component 3
- JFY1
- JFY-1
- p53 up-regulated modulator of apoptosis
- PUMAFLJ42994
Background
A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.