CaMKIV Antibody Summary
| Immunogen |
Synthetic Peptide: V(127) E K G Y Y S E R D A A D A V K Q(143) C
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| Localization |
Cytoplasmic and Nuclear
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| Specificity |
NB120-3557 detects CaM kinase IV (CaMKIV) from human, mouse, rat, canine, primate, arabidopsis and Xenopus Oocyte samples.
|
| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
|
| Gene |
CAMK4
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Detects an approx. 55 kDa protein representing CaMKIV in HeLa cell lysate.
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for CaMKIV Antibody
- brain Ca(2+)-calmodulin-dependent protein kinase type IV
- brain Ca++-calmodulin-dependent protein kinase type IV
- calcium/calmodulin-dependent protein kinase IV
- calcium/calmodulin-dependent protein kinase type IV catalytic chain
- calcium/calmodulin-dependent protein kinase type IV
- CAM kinase- GR
- CAM kinase IV
- CaM kinase-GR
- CaMK IV
- caMK
- CaMK-GR
- EC 2.7.11
- EC 2.7.11.17
- IV
- MGC36771
Background
CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C / EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.