CBLB Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 450 and 500 of human Cas-Br-M (murine) Ecotropic Retroviral Transforming Sequence b using the numbering given in entry NP_733762.2 (GeneID 868).
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| Predicted Species |
Mouse (100%), Rat (100%), Primate (100%), Monkey (100%), Chinese Hamster (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CBLB
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
This antibody reacts with Human. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crab-eating macaque and Chinese hamster.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CBLB Antibody
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b
- Cas-Br-M (murine) ectropic retroviral transforming sequence b
- Casitas B-lineage lymphoma proto-oncogene b
- DKFZp686J10223
- DKFZp779A0729
- DKFZp779F1443
- E3 ubiquitin-protein ligase CBL-B
- EC 6.3.2
- EC 6.3.2.-
- FLJ41152
- RING finger protein 56
- RNF56FLJ36865
- SH3-binding protein CBL-B
- Signal transduction protein CBL-B
Background
CBLB is an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.