dystrophia myotonica containing WD repeat motif Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 609 and 659 of human dystrophia myotonica, WD repeat containing using the numbering given in entry NP_004934.1 (GeneID 1762).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
DMWD
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
|
Alternate Names for dystrophia myotonica containing WD repeat motif Antibody
- D19S593E
- DM9
- DMRN9
- DMR-N9
- dystrophia myotonica WD repeat-containing protein
- dystrophia myotonica, WD repeat containing
- Dystrophia myotonica-containing WD repeat motif protein
- dystrophia myotonica-containing WD repeat motif
- gene59
- Protein 59
- Protein DMR-N9
Background
The gene that codes for DMWD (dystrophia myotonica WD-repeat containing protein) is located in the myotonic dystrophy (DM1) gene cluster on 19q. Mutations in the DM1 region affect DMPK (myotonic dystrophy protein kinase), a myosin kinase expressed in skeletal muscle, and are the cause of myotonic dystrophy, a form of muscular dystrophy characterized by wasting of the muscles and myotonia. DMWD is expressed ubiquitously and is most abundant in the testes and brain. Studies concerning its abundance and sub-cellular localization in brain tissue suggest that it may have a role in some of the mental symptoms associated with myotonic dystrophy.