UGT1A6 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human UGT1A6. The exact sequence is proprietary.
|
| Localization |
Microsome, Endoplasmic reticulum membrane, Single-pass membrane protein
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
UGT1A6
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.56 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for UGT1A6 Antibody
- GNT1UDPGT 1-6
- HLUGP
- HLUGP1
- MGC29860
- Phenol-metabolizing UDP-glucuronosyltransferase
- UDP glucuronosyltransferase 1 family, polypeptide A6
- UDP glycosyltransferase 1 family, polypeptide A6
- UDP-glucuronosyltransferase 1 family polypeptide A6s
- UDP-glucuronosyltransferase 1-6
- UDP-glucuronosyltransferase 1A6
- UDP-glucuronosyltransferase 1-F
- UDPGT
- UGT1
- UGT1*6
- UGT1.6
- UGT1-06
- UGT1A6S
- UGT-1F
- UGT1FEC 2.4.1.17
Background
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5 end of this gene results in two transcript variants.