HERPUD1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human HERPUD1. The exact sequence is proprietary.
|
| Localization |
Endoplasmic reticulum membrane; Single-pass membrane protein
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
HERPUD1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
44 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for HERPUD1 Antibody
- HERPMIF1
- homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-likedomain member 1 protein
- homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-likedomain member 1
- homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domainmember 1 protein
- KIAA0025MMS-inducible
- Methyl methanesulfonate (MMF)-inducible fragment protein 1
- Mif1
- SUP
Background
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq]