SAP102 Antibody (7D3) Summary
| Immunogen |
Recombinant rat SAP102 (N-terminal fragment).
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
DLG3
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody is useful in Immunohistochemistry, Immunoprecipitation and detects a band of ~102kDa by Western blot.
|
Reactivity Notes
Mouse and Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS and 50% Glycerol
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for SAP102 Antibody (7D3)
- discs, large homolog 3 (Drosophila)
- KIAA1232discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
- MRX90MRX
- NEDLGdisks large homolog 3
- neuroendocrine-DLG
- SAP-102
- SAP102NE-Dlg
- Synapse-associated protein 102
- XLMR
Background
Synapse-associated proteins SAP97 and SAP102 display extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminals. In addition to the CNS, SAP97 is also detected at the basal lateral membrane between a variety of epithelial cells. SAP102 associates with NMDA receptors through the C-terminal NR2B subunit of the receptor. The N-terminal SAP97 PDZ domain mediates its interaction with the synaptic ras-GTPase activating protein SynGAP.