MRP4/ABCC4 Antibody (M4I-80) Summary
| Immunogen |
The antibody reacts with the MRP4 antigen.
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| Specificity |
The M4I-80 Mab was selected after immunization with a fusion protein containing the E. coli maltose binding protein and a fragment of the human MRP4 protein corresponding to amino acids 372-431. MRP4 transports cyclic nucleotides and anti-retroviral compounds. The M4I-80 Mab also reacts with the mouse orthologue of the transporter molecule (Mrp4).
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| Isotype |
IgG2a
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| Clonality |
Monoclonal
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| Host |
Rat
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| Gene |
ABCC4
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| Purity |
Tissue culture supernatant
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Immunocytochemistry: use 1:20-50 dil. on acetone fixed cytospin preparations. For immunohistochemistry: M4I- 80 (use 1:20) on acetone fixed frozen sections can be followed by incubation with biotin-labeled rabbit anti-rat IgG (1:100) and HRP-labeled
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
0.7% BSA
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| Preservative |
0.1% Sodium Azide
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| Purity |
Tissue culture supernatant
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Alternate Names for MRP4/ABCC4 Antibody (M4I-80)
- ABCC4
- ATP-binding cassette sub-family C member 4
- ATP-binding cassette, sub-family C (CFTR/MRP), member 4
- EST170205
- MOATB
- MOAT-BbA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
- MOATBcanalicular multispecific organic anion transporter (ABC superfamily)
- MRP4
- MRP4MRP/cMOAT-related ABC transporter
- multidrug resistance-associated protein 4
- multispecific organic anion transporter B
- Multi-specific organic anion transporter B
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.