SLPI Antibody (31) Summary
| Immunogen |
The antibody reacts specificly with secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease (ALP)).
|
| Specificity |
The antibody reacts specificly with secretory leukocyte proteinase inhibitor (SLPI; also known as antileukoprotease (ALP)).
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SLPI
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS containing 0.1% BSA
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
0.1 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for SLPI Antibody (31)
- ALK1
- ALPProtease inhibitor WAP4
- antileukoproteinase
- BLPISeminal proteinase inhibitor
- HUSI
- HUSI-I
- Mucus proteinase inhibitor
- secretory leukocyte peptidase inhibitor
- secretory leukocyte protease inhibitor (antileukoproteinase)
- Secretory leukocyte protease inhibitor
- SLPI
- WAP four-disulfide core domain protein 4
- WAP4HUSI-1
- WFDC4MPI
Background
SLPI is a 11.7 kDa cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs and by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).