Product: GLPG0494 (R enantiomer)
Cytochrome P450 2E1 Antibody Summary
| Immunogen |
Synthetic peptide surrounding amino acid 405 of human Cytochrome p450.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CYP2E1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Western blotting (0.5-4 ug/ml).However, the optimal conditions should be determined individually. The antibody detects ~58kDa cytochrome P450 IIE1 from samples of human, mouse, rat and dog origins.
|
| Theoretical MW |
57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS, 0.5% BSA and 30% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Cytochrome P450 2E1 Antibody
- 4-nitrophenol 2-hydroxylase
- CPE1
- CYP2Ecytochrome P450 2E1
- CYPIIE1
- cytochrome P450, family 2, subfamily E, polypeptide 1
- cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
- Cytochrome P450-J
- EC 1.14.13.-
- EC 1.14.13.n7
- EC 1.14.14.1
- flavoprotein-linked monooxygenase
- microsomal monooxygenase
- P450C2E
- P450-J
- xenobiotic monooxygenase
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.