IL-17/IL-17A Antibody Summary
| Immunogen |
Antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human IL-17A. The immunogen is located within amino acids 40 – 90 of IL-17.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
IL17A
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IL-17 antibody can be used for the detection of IL-17 by Western blot at 2 – 4 mg/ml.
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| Theoretical MW |
17 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Control Peptide |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for IL-17/IL-17A Antibody
- CTLA-8
- CTLA8cytotoxic T-lymphocyte-associated serine esterase 8
- Cytotoxic T-lymphocyte-associated antigen 8
- IL17
- IL-17
- IL17A
- IL-17A
- IL-17Acytotoxic T-lymphocyte-associated protein 8
- IL-17CTLA-8
- IL17interleukin-17A
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
- interleukin 17A
Background
Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.