Cyclin D1 Antibody (CD1.1) Summary
| Immunogen |
Human Cyclin D1
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| Specificity |
Recognizes the Cyclin D1, a 36kD nuclear protein. D type cyclins are predominantly expressed in the G1 phase of the cell cycle. Cyclin D1 study is of interest in various forms of malignancy, and over expression has been linked to poor prognosis.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
CCND1
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Membrane permeabilization is required for Flow Cytometry. This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose.
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for Cyclin D1 Antibody (CD1.1)
- B-cell lymphoma 1 protein
- BCL-1 oncogene
- Bcl-1
- BCL1D11S287E
- CCND1
- cyclin D1 (PRAD1: parathyroid adenomatosis 1)
- Cyclin D1
- Cyl-1
- G1/S-specific cyclin D1
- G1/S-specific cyclin-D1
- PRAD1 oncogene
- PRAD1
- PRAD1B-cell CLL/lymphoma 1
- U21B31
Background
During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by acting as regulatory subunits of the Cdks. Early in the G1 phase of the cell cycle, cyclin D1 induction is followed by cyclin E induction. This sequential progression is marked early on in G1 by the activation of Cdk4 and in mid to late G1 by the activation of Cdk2 and the hyperphosphorylation of pRB. The final transition into S phase is thought to be dependent on the increased expression and association of cyclin E and Cdk2. In a recent study, Cyclin D1 regulates cellular metabolism, fat cell differentiation and cellular migration. Cyclin D1 is also involved in development and cancer.