S100A/B Antibody Summary
| Immunogen |
Recombinant full length S-100 protein isolated from Cow brain.
|
| Localization |
Cytoplasmic
|
| Specificity |
This antibody reacts with cow S-100 protein a and b. It shows strong crossreactivity with human S-100 a and b. In the brain, it labels glial and ependymal cells. Melanocytes and Langerhans cells of the skin stain positive with this antibody.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
S100A1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Cross-reacts with Human and Cow. Expected to cross react with Rat and Pig.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.3) and protein carrier
|
| Preservative |
Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for S100A/B Antibody
- protein S100-A1
- S100 alpha
- S100 calcium binding protein A1
- S100 calcium-binding protein A1S100
- S-100 protein alpha chain
- S-100 protein subunit alpha
- S100 protein, alpha polypeptide
- S100A
- S100-alpha
Background
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwanns cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumors of the skin, and in Langerhans cells in the skin.