Noggin Antibody Summary
| Immunogen |
Synthetic peptide comprising residues 156-170 [PVLYAWNDLGSRFWP] of the human Noggin protein
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| Specificity |
This is specific to the NOG protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NOG
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful for Western Blot.
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| Positive Control |
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Reactivity Notes
Reacts with Human, mouse and rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Noggin Antibody
- NOG
- Noggin
- SYM1
- symphalangism 1 (proximal)
- synostoses (multiple) syndrome 1
- SYNS1
Background
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.