Product: Nalfurafine (hydrochloride)
TSH R Antibody (49) Summary
| Immunogen |
Purified extracellular domain of recombinant human thyrotropin receptor.
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| Epitope |
This antibody recognizes an epitope between amino acid residues 277-296 of human TSH receptor.
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| Localization |
Cell Membrane
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| Specificity |
NB120-5492 detects both glycosylated and nonglycosylated thyroid stimulating hormone receptor (TSHR) from porcine tissues as well as recombinant human TSHR.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
TSHR
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| Purity |
Unpurified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Detects an approx. 50 kDa and a 63 kDa protein representing unglycosylated and glycosylated TSHR respectively, in transfected Sf9 cell extract. ELISA: Used in TSH competitive inhibition studies.
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
Ascites with PBS
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| Preservative |
0.05% Sodium Azide
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| Purity |
Unpurified
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Alternate Names for TSH R Antibody (49)
- CHNG1
- LGR3
- LGR3hTSHR-I
- MGC75129
- seven transmembrane helix receptor
- thyroid stimulating hormone receptor
- Thyroid-stimulating hormone receptor
- thyrotropin receptor
- thyrotropin receptor-I, hTSHR-I
- TSH R
- TSHR
- TSH-R
Background
The thyroid stimulating hormone (thyrotropin) receptor (TSHR) is expressed on the surface of thyrocyte cell membranes and is crucial for thyroid gland growth and function. TSHRs are targets for the pathogenesis of many autoimmune diseases including Graves disease and primary myxedema. This 7-transmembrane-domain protein contains 5 potential extracellular N-linked glycosylation sites. Antibodies to TSHR can affect receptor function in a number of different ways. TSHR antibodies which can inhibit TSH binding to the receptor are called TSH binding inhibitor immunoglobulins or TBIIs.