Product: Mexiletine (hydrochloride)
beta-TrCP1/BTRC Antibody (3D5) Summary
| Immunogen |
Human fragment corresponding to amino acids 52-372 of human BTRC (NP_378663) produced in E.coli.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
BTRC
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
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| Preservative |
0.02% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for beta-TrCP1/BTRC Antibody (3D5)
- beta-transducin repeat containing
- betaTrCP
- BETA-TRCP
- betaTrCP1
- beta-TrCP1
- BTRC
- BTRCP
- bTrCP1
- E3RSIkappaB
- F-box and WD repeats protein beta-TrCP
- F-box/WD repeat-containing protein 1A
- FBW1A
- FBXW1
- FBXW1A
- FBXW1ABTRCP
- FWD1
- MGC4643
- pIkappaBalpha-E3 receptor subunit
Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway. [provided by RefSeq].