Product: Testosterone (undecanoate)
DNMT1 Antibody Summary
| Immunogen |
The immunogen this antibody was made to, maps to a region between residues 350-400 of human DNAMethyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
DNMT1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Western Blot, where a band should be seen at 190 kDa. This antibody is not recommended for IP. Other applications have not been tested. *Suggested Working Dilutions: Western blot: 1:1,000-1:10,000 Immunoprecipitation: not recommended (use NB 100-392 for IP) Immunohistochemistry: not tested *Optimal working dilutions should be determined experimentally by the investigator.
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| Positive Control |
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| Publications |
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for DNMT1 Antibody
- AIM
- CXXC9
- CXXC9CXXC finger protein 9
- CXXC-type zinc finger protein 9
- DNA (cytosine-5-)-methyltransferase 1
- DNA (cytosine-5)-methyltransferase 1
- DNA methyltransferase 1
- DNA methyltransferase HsaI
- DNA MTase HsaI
- DNMT
- DNMT1
- EC 2.1.1.37
- FLJ16293
- m.HsaI
- MCMT
- MCMTMGC104992
Background
Inactivation of tumor suppressor genes is a key component of the development of all common forms of human cancers. Aberrant methylation may contribute to many of the changes, both physiological and pathological, associated with aging, including tumor development. Hypermethylation of CpG island-containing promoters is associated with the inactivation of genes important to tumor angiogenesis and progression. DNA methytransferase (DNMT1) is necessary for the maintenance of the methylation process.