Product: Mephentermine (sulfate)
TFIP11 Antibody Summary
| Immunogen |
The immunogen for this product maps to a region between residue 1 and 50 of human tuftelin interacting protein 11 using the numbering given in entry NP_036275.1 (GeneID 24144).
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
TFIP11
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
TBS and 0.1% BSA
|
| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for TFIP11 Antibody
- bK445C9.6
- DKFZP434B194
- FLJ22086
- hNtr1
- NTR1
- Septin and tuftelin-interacting protein 1
- STIP
- STIP-1
- TIP39Spp382
- tuftelin interacting protein 11
- tuftelin-interacting protein 11
Background
Neurotensin (NT) initiates an intracellular response by interacting with the G protein-coupled receptors NTR1 (NTS1 receptor, high affinity NTR) and NTR2 (NTS2 receptor, levocabastine-sensitive neurotensin receptor), and the type I receptor NTR3 (NTS3 receptor, sortilin-1, Gp95). NT has a wide distribution in regions of the brain and in peripheral tissues where NT receptors can contribute to hypotension, hyperglycemia, hypothermia, antinociception and regulation of intestinal motility and secretion. HL-60 cells express NTR1, which can couple to Gq, Gi/o, or Gs. Alternative splicing of rat NTR2 can generate a 5-transmembrane domain variant isoform that is co-expressed with the full-length NTR2 throughout the brain and spinal cord. NTR3 activation in the murine microglial cell line N11 induces MIP-2, MCP-1, IL-1beta and TNFalpha in an ERK1/2 and Akt kinase-dependent manner.