ZAP70 [p Tyr319] Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region including tyrosine 319 (when it is phosphorylated) of human zeta-chain (TCR) associated protein kinase 70kDa using the numbering given in entry NP_001070.2 (GeneID 7535).
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| Modification |
p Tyr319
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ZAP70
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody is useful for immunoprecipitation and flow cytometry (1.0 mcg per 1 X 10e6 cells in a 150mcl volume). It is not recommended for western blot.
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ZAP70 [p Tyr319] Antibody
- 70 kDa zeta-associated protein
- EC 2.7.10
- EC 2.7.10.2
- mrtle
- mur
- SRK
- SRKFLJ17679
- STD
- STDFLJ17670
- Syk-related tyrosine kinase
- tyrosine-protein kinase ZAP-70
- TZK
- ZAP70
- ZAP-70
- zeta-chain (TCR) associated protein kinase (70 kD)
- zeta-chain (TCR) associated protein kinase 70kDa
- zeta-chain associated protein kinase, 70kD
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]