PP2C beta/PPM1B Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 450 and the C-terminus (residue 479) of human Protein Phosphatase 1B, Magnesium-Dependent, Beta Isoform using the numbering given in entry NP_002697.1 (GeneID 5495).
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| Predicted Species |
Monkey (100%), Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PPM1B
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
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| Positive Control |
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| Publications |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crab-eating macaque, Chinese hamster, Naked mole rat, Small-eared galago and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
TBS and 0.1% BSA
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PP2C beta/PPM1B Antibody
- EC 3.1.3.16
- MGC21657
- PP2C beta
- Pp2c2
- PP2CB
- PP2C-beta
- PP2C-beta-X
- PP2CBmagnesium-dependent, beta isoform
- PPM1B
- protein phosphatase 1B
- Protein phosphatase 2C isoform beta
- protein phosphatase 2C-like protein
- protein phosphatase, Mg2+/Mn2+ dependent, 1B
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences