Product: Levobunolol (hydrochloride)
Smad3 Antibody (5G11) Summary
| Immunogen |
Purified recombinant fragment of human SMAD3 expressed in E. Coli.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
SMAD3
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human, Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
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| Preservative |
0.03% Sodium Azide
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| Purity |
Unpurified
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Alternate Names for Smad3 Antibody (5G11)
- DKFZp586N0721
- DKFZp686J10186
- hMAD-3
- hSMAD3
- HsT17436
- JV15-2MGC60396
- MAD homolog 3
- mad protein homolog
- MAD, mothers against decapentaplegic homolog 3 (Drosophila)
- MAD, mothers against decapentaplegic homolog 3
- mad3
- MADH3mad homolog JV15-2
- mothers against decapentaplegic homolog 3
- Mothers against DPP homolog 3
- SMA- and MAD-related protein 3
- SMAD 3
- SMAD family member 3HSPC193
- SMAD, mothers against DPP homolog 3 (Drosophila)
- SMAD, mothers against DPP homolog 3
- Smad3
Background
Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-beta/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions (1). Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-beta), an inhibitor for tumor cell proliferation (2). Smad3 is activated by activin/TGF-beta receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF-beta target genes. Interaction of Smad3 with Akt, can initiate TGF-beta induced apoptosis and cell cycle arrest (3). Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis