Product: Taurocholic Acid (sodium hydrate)
KIR3DL1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human CD158e. The exact sequence is proprietary.
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| Localization |
Cell membrane, Single-pass type I membrane protein
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| Predicted Species |
Primate (90%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
KIR3DL1
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| Purity |
Immunogen affinity purified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IHC-Fr usage reported in scientific literature (PMID: 24815059).
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|
| Theoretical MW |
49 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
Rat reactivity reported in scientific literature (PMID: 26679227). Chimpanzee (90%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for KIR3DL1 Antibody
- AMB11
- CD158 antigen-like family member E
- CD158e antigen
- CD158E
- CD158e1
- CD158e1/2
- CD158e2
- cl-11
- cl-2
- HLA-BW4-specific inhibitory NK cell receptor
- killer cell immunoglobulin-like receptor 3DL1
- killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail1,nkat3
- killer Ig receptor
- KIR antigen 3DL1
- KIR3DL1
- KIR3DL1/S1
- KIR3DS1
- MGC119726
- MGC119728
- MGC126589
- MGC126591
- MHC class I NK cell receptor
- Natural killer-associated transcript 3
- Nkat3
- NKAT-3
- NKAT3KIR
- NKB1
- NKB1B
- NKB1CD158E1
- NK-receptor
- p70 killer cell inhibitory receptor
- p70 natural killer cell receptor clones CL-2/CL-11
- p70 NK receptor CL-2/CL-11
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several “framework” genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq]