IMP Dehydrogenase 2/IMPDH2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human IMPDH2. The exact sequence is proprietary.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
IMPDH2
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus laevis (88%), Zebrafish (87%), Xenopus tropicalis (89%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
0.17 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for IMP Dehydrogenase 2/IMPDH2 Antibody
- EC 1.1.1.205
- IMDH2
- IMP (inosine 5-monophosphate) dehydrogenase 2
- IMP (inosine monophosphate) dehydrogenase 2
- IMP Dehydrogenase 2
- IMP Oxireductase 2
- IMPD 2
- IMPD2
- IMPD2IMP oxireductase 2
- IMPDH 2
- IMPDH2
- IMPDH-II
- inosine 5 phosphate dehydrogenase 2
- inosine monophosphate dehydrogenase type II
- inosine-5-monophosphate dehydrogenase 2
Background
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.