DAP5 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human DAP5. The exact sequence is proprietary.
|
| Predicted Species |
Rabbit (100%), Bovine (100%). Backed by our 100% Guarantee.
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| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
EIF4G2
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.39 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for DAP5 Antibody
- aging-associated protein 1
- DAP-5
- DAP5AAG1
- Death-associated protein 5
- eIF4G 2
- eIF-4G 2
- eIF-4-gamma 2
- eukaryotic translation initiation factor 4 gamma 2
- eukaryotic translation initiation factor 4 gamma, 2
- eukaryotic translation initiation factor 4G-like 1
- FLJ41344
- NAT1
- p97
Background
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.