ATP6V1H Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human ATP6V1H. The exact sequence is proprietary.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ATP6V1H
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.56 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for ATP6V1H Antibody
- ATPase, H+ transporting, lysosomal 50/57kD, V1 subunit H
- ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
- CGI-11
- MSTP042
- NBP1
- Nef-binding protein 1
- Protein VMA13 homolog
- SFD
- SFDalpha
- SFDbeta
- vacuolar ATP synthase subunit H
- vacuolar ATPase subunit H
- vacuolar proton pump H subunit
- Vacuolar proton pump subunit H
- Vacuolar proton pump subunit SFD
- V-ATPase 50/57 kDa subunits
- V-ATPase H subunit
- V-ATPase subunit H
- VMA13
- V-type proton ATPase subunit H
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c”, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the regulatory H subunit of the V1 domain which is required for catalysis of ATP but not the assembly of V-ATPase. Three alternatively spliced transcript variants encode two isoforms of the H subunit.