Stathmin 1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human Stathmin 1. The exact sequence is proprietary.
|
| Localization |
Cytoplasm
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
STMN1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.52 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Stathmin 1 Antibody
- C1orf215
- chromosome 1 open reading frame 215
- Lag
- Leukemia-associated phosphoprotein p18
- metablastin
- MGC138869
- Oncoprotein 18
- Op18
- OP18MGC138870
- phosphoprotein 19
- Phosphoprotein p19
- PP17
- PP19
- PR22
- prosolin
- Protein Pr22
- SMNLAP18FLJ32206
- stathmin 1
- stathmin 1/oncoprotein 18
- stathmin
- transmembrane protein C1orf215
Background
Stathmin (oncoprotein 18, op18) is a ubiquitous cytosolic phosphoprotein with various regulatory functions in cell proliferation, differentiation signaling, and activation (1). In particular, stathmin is involved in the regulation of tubulin dynamics through inhibition of microtubule formation and/or microtubule depolymerization. Stathmin interacts with soulable tubulins (alpha,beta-tubulin) resulting in the formation of T2S complex which sequesters free tubulin, impeding tubulin formation (2). Stathmin activity is regulated through phosphorylation at Ser16, Ser25, Ser38 and Ser63 by various protein kinases (e.g. MAP-kinase, p34cdc2 kinase), weakening stathmins affinity to tubulin (3). A mutation on stathmin can lead to excess build up of mitotic spindle and with possible consequence of unregulated cell cycles seen in cancer cells (4). Stathmin is also known as the generic member of a protein family which includes neural proteins SCG10, SCLIP and RB3/RB3/RB3″. All members in this family exhibits tubulin binding ability.