JIP2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human JIP2. The exact sequence is proprietary.
|
| Localization |
Cytoplasm
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| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
MAPK8IP2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for JIP2 Antibody
- C-Jun-amino-terminal kinase-interacting protein 2
- homologous to mouse JIP-1
- IB-2
- IB2JIP2Mitogen-activated protein kinase 8-interacting protein 2
- islet-brain 2
- islet-brain-2
- JIP-2
- JNK MAP kinase scaffold protein 2
- JNK MAP kinase scaffold protein JIP2
- JNK-interacting protein 2
- mitogen-activated protein kinase 8 interacting protein 2
- PRKM8 interacting protein-like
- PRKM8IPL
Background
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites, Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members have been identified as JNK2 and JNK3. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.