Proteasome 20S alpha 6 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human Proteasome 20S alpha 6. The exact sequence is proprietary.
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| Localization |
Cytoplasm, Nucleus
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| Isotype |
IgG
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| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PSMA6
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Expected cross reactivity based on sequence homology: Rhesus Monkey (100%) and Chimpanzee (100%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Proteasome 20S alpha 6 Antibody
- EC 3.4.25.1
- IOTA
- Macropain iota chain
- macropain subunit iota
- MGC22756
- MGC2333
- MGC23846
- Multicatalytic endopeptidase complex iota chain
- P27K
- p27KPROS-27
- PROS2727 kDa prosomal protein
- prosomal P27K protein
- proteasome (prosome, macropain) subunit, alpha type, 6
- Proteasome iota chain
- proteasome subunit alpha type-6
- proteasome subunit iota
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.