CRMP5 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human CRMP5. The exact sequence is proprietary.
|
| Localization |
Cytoplasm
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
DPYSL5
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1.01 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for CRMP5 Antibody
- Collapsin response mediator protein 5
- collapsin response mediator protein-5
- CRAMCRMP3-associated molecule
- CRMP-5FLJ45383
- CRMP5UNC33-like phosphoprotein 6
- dihydropyrimidinase-like 5
- dihydropyrimidinase-related protein 5
- DRP-5
- Ulip6
- ULIP-6
Background
The collapsin response mediator protein (CRMP) family of proteins (also referred to as ULIP6) are a group of neurologic proteins that have been found to play key roles in growth cone guidance during neural development. CRMP5 has relatively low sequence homology with the other four members of the CRMP family. CRMP5 is expressed in the developing nervous system in an expression pattern that resembles CRMP2 and has a peak expression during the first postnatal week. Elevated levels of autoantibody to CRMP5 have been shown to be linked paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms.Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is also being investigated as an oncological marker in the respiratory system and in the thymus.