UbcH5a/UBE2D1 Antibody Summary
| Immunogen |
Full length human UBE2D1 Recombinant protein.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
UBE2D1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for UbcH5a/UBE2D1 Antibody
- E2(17)KB1
- Stimulator of Fe transportUBC4/5 homolog
- UBC4/5
- UBC5A
- UbcH5
- UbcH5a
- UBCH5AEC 6.3.2.19
- UBCH5SFT
- UBE2D1
- Ubiquitin carrier protein D1
- ubiquitin-conjugating enzyme E2 D1
- Ubiquitin-conjugating enzyme E2(17)KB 1
- Ubiquitin-conjugating enzyme E2-17 kDa 1
- ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
- Ubiquitin-protein ligase D1
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.