Product: Lenampicillin (hydrochloride)
NGF R/TNFRSF16/p75NTR Antibody Summary
| Immunogen |
A synthetic peptide from the extracellular domain of human p75NTR/NGF (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the immunogen.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NGFR
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human, Mouse and Rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
IgG purified
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| Reconstitution Instructions |
Reconstitute with 0.5 ml sterilized water. Add glycerol (1:1) for additional stability.
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Alternate Names for NGF R/TNFRSF16/p75NTR Antibody
- CD271 antigen
- CD271
- Gp80-LNGFR
- member 16
- nerve growth factor receptor
- NGF R
- NGF receptor
- NGFR
- p75 ICD
- p75 NTR
- TNFRSF16
- TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16)
- tumor necrosis factor receptor superfamily member 16
Background
FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.