SEC61A Antibody Summary
| Immunogen |
Peptide with sequence C-KEQSEVGSMGALLF corresponding to C-Terminus according to NP_037468.1.
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| Epitope |
C-KEQSEVGSMGALLF
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
SEC61A1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 48 kDa band observed in human brain (Cerebelum) lysates (calculated MW of 52.3 kDa band according to NP_037468.1).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Canine, Bovine, Porcine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for SEC61A Antibody
- HSEC61
- protein transport protein SEC61 alpha subunit
- protein transport protein Sec61 subunit alpha isoform 1
- protein transport protein Sec61 subunit alpha
- Sec61 alpha 1 subunit (S. cerevisiae)
- Sec61 alpha-1
- sec61 homolog
- SEC61
- SEC61A
Background
SEC61A1 belongs to the SECY/SEC61 alpha family. It has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum.The SEC61 complex is responsible for translocation of proteins across the rough endoplasmic reticulum membrane. SEC61 is composed of three subunits: alpha, beta, and gamma; that associate to form a heterotrimer. Multiple heterotrimers associate forming the ER translocon. SEC61 alpha is a polytopic protein that has ten membrane-spanning loops. SEC61 has been found to be tightly associated with membrane bound ribosomes, either directly or through adaptor proteins, and is required for assembly of membrane and secretory proteins.