Product: Benzophenonetetracarboxylic acid
IDH2 Antibody Summary
| Immunogen |
Peptide with sequence CIHGLSNVKLNE corresponding to internal region according to NP_002159.2.
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| Epitope |
CIHGLSNVKLNE
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
IDH2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 48 kDa band observed in mouse, rat and porcine heart lysates (calculated MW of 50.9 kDa band according to mouse NP_766599.2).
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Canine, Bovine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Purity |
Immunogen affinity purified
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Alternate Names for IDH2 Antibody
- D2HGA2
- EC 1.1.1.42
- ICD-M
- IDH
- IDHM
- IDP
- IDPM
- isocitrate dehydrogenase [NADP], mitochondrial
- isocitrate dehydrogenase 2 (NADP+), mitochondrial
- mNADP-IDH
- NADP(+)-specific ICDH
- Oxalosuccinate decarboxylase
Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.